In one clinical trial, buspirone was administered to healthy male volunteers at a dosage of 375 mg/day, and produced side effects including nausea, vomiting, dizziness, drowsiness, miosis, and gastric distress. Overdose īuspirone appears to be relatively benign in cases of single-drug overdose, although no definitive data on this subject appear to be available. It is unclear if there is a risk of tardive dyskinesia or other movement disorders with buspirone. Dyskinesia, akathisia, myoclonus, parkinsonism, and dystonia were reported associated with buspirone. In addition, buspirone does not produce euphoria and is not a drug of abuse. Buspirone is relatively well tolerated, and is not associated with sedation, cognitive and psychomotor impairment, muscle relaxation, physical dependence, or anticonvulsant effects. Known side effects associated with buspirone include dizziness, headaches, nausea, tinnitus, and paresthesia. Main article: List of side effects of buspirone Severely compromised liver and/or kidney function.Contraindications īuspirone has these contraindications: SSRI and SNRI antidepressants such as paroxetine and venlafaxine may cause jaw pain/jaw spasm reversible syndrome (although it is not common), and buspirone appears to be successful in treating bruxism on SSRI/SNRI-induced jaw clenching. Miscellaneous īuspirone is not effective as a treatment for benzodiazepine withdrawal, barbiturate withdrawal, or alcohol withdrawal/ delirium tremens. Buspirone may also be effective in treating antidepressant-induced sexual dysfunction. There is some evidence that buspirone on its own may be useful in the treatment of hypoactive sexual desire disorder (HSDD) in women. Buspirone is not known to be effective in the treatment of other anxiety disorders besides GAD, although there is some limited evidence that it may be useful in the treatment of social phobia as an adjunct to selective serotonin reuptake inhibitors (SSRIs). The drug has been shown to be similarly effective in the treatment of generalized anxiety disorder (GAD) to benzodiazepines including diazepam, alprazolam, lorazepam, and clorazepate. īuspirone has no immediate anxiolytic effects, and hence has a delayed onset of action its full clinical effectiveness may require 2–4 weeks to manifest itself. It is generally preferred over benzodiazepines because it does not activate the receptors that make drugs like alprazolam addictive. īuspirone is used for the short-term and long-term treatment of anxiety disorders or symptoms of anxiety. In 2020, it was the 55th most-commonly prescribed medication in the United States, with more than 12 million prescriptions. īuspirone was first made in 1968 and approved for medical use in the United States in 1986. It is a serotonin 5-HT 1A receptor agonist. Its use in pregnancy appears to be safe but has not been well studied, while use during breastfeeding has not been well studied. Serious side effects may include movement disorders, serotonin syndrome, and seizures. Ĭommon side effects of buspirone include nausea, headaches, dizziness, and difficulty concentrating. It is taken orally (by mouth), and takes two to six weeks to be fully effective. īe sure to check with your doctor or pharmacist when in doubt.Buspirone, sold under the brand name Buspar, among others, is a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder. Pill splitting is also not recommended for situations where the patient might not understand the concept or be capable of splitting a pill. Don't split drugs with an enteric coating (designed to protect the stomach), drugs that are time-release or long-acting, drugs taken more often than once a day, drugs in capsules, and prepackaged drugs in specific doses, like birth control pills. Some immediate-release tablets may be split, and tablets that are scored have been evaluated by the FDA for safety. Pill splitters can be bought at most pharmacies for around $5. Some important things to consider before pill splitting: You'll need to ask your doctor if pill splitting is a good idea for your prescription if so, they will need to adjust your prescription accordingly. While it may seem odd, the 40mg version of the same drug typically does not cost twice as much as the 20mg-in fact, it often costs the exact same amount! Here's how it works: Imagine you take the 20mg dosage of a certain drug. You may be able to save up to 50% each month by splitting a higher dosage of this drug.
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